Fig 8. Changes in transcript levels in wild-type B. burgdorferi during nutrient stress.

Genes significantly differentially expressed more than twofold as determined by RNA-seq of wild-type B31-5A4 (A) shifted from stationary phase to starvation (6 h RPMI) and (B) in recovery (2 h BSK + RS) from starvation. The number of genes upregulated (black bars) and downregulated (gray bars) are divided by functional category using the following abbreviations: BP, bacteriophage; CD, cell division; CE, cell envelope; CM, chemotaxis and motility; MT, metabolism; PD, protein degradation; RR, DNA replication and repair; SR, stress response; TL, translation; TP, transporter proteins; TR, transcription and transcriptional regulation; and U, unknown.