Fig. 3.

MiR-193b targets FASN and induces apoptosis of TNBC cells, but not normal mammary epithelial cells. a Mature miR-193b levels are assessed in luminal A and TN breast cancer cells by qRT-PCR. b Transfection of miR-193b mimic into BT-549 cells for 72 h decreases FASN protein and increases apoptosis as detected by PARP cleavage. c Transfection of a miR-193b mimic into BT-549 cells for 72 h causes a dose-dependent decrease in FASN and induction of apoptosis. d No apoptosis is observed when miR-193b is transfected into MCF10A (normal immortalized) cells