Table 1.
Top 15 Genes downregulated by 10 mM metformin treatment for 24 h in MDA-MB-468 cells at 5 mM glucose
| Gene name | Description | Fold change |
|---|---|---|
| SQLE | Squalene epoxidase | −8.9 |
| FASNa | Fatty acid synthase | −8.2 |
| HMGCS1 | 3-Hydroxy-3-methylglutaryl-CoA synthase 1 | −8.0 |
| TF | Transferrin | −6.7 |
| LSSa | Lanosterol synthase | −6.7 |
| INSIG1 | Insulin-induced gene 1 | −6.1 |
| SKA2 | Spindle and kinetochore-associated complex subunit 2 | −6.0 |
| HIST1H3A | Histone cluster 1, H3a | −5.7 |
| HIST1H1A | Histone cluster 1, H1a | −5.6 |
| ACAT2 | Acetyl-CoA acetyltransferase 2 | −5.5 |
| MVD | Mevalonate (diphospho)decarboxylase | −5.3 |
| HMGCR | 3-Hydroxy-3-methylglutaryl-CoA reductase | −5.3 |
| PCSK9 | Proprotein convertase subtilisin/kexin type 9 | −5.3 |
| DHCR24 | 24-Dehydrocholesterol reductase | −5.0 |
| IL22RA2 | Interleukin 22 receptor, alpha 2 | −5.0 |
aThese genes were also significantly downregulated in MDA-MB-231 treated with 10 mM metformin at 5 mM glucose