Table 2.
Top fatty acid biosynthetic and lipid metabolic/biosynthesis processes altered by metformin in MDA-MB-468 cells
| Gene name | Description | Fold change |
|---|---|---|
| FASNa | Fatty acid synthase | −8.2 |
| HMGCS1 | 3-Hydroxy-3-methylglutaryl-CoA synthase 1 | −8.0 |
| ACAT2 | Acetyl-CoA acetyltransferase 2 | −5.5 |
| SCD | Stearoyl-CoA desaturase | −4.31 |
| ACLY | ATP-citrate lyase | −4.26 |
| ACSL1 | Acyl-CoA synthetase long-chain family member 4 | −2.69 |
| PC | Pyruvate carboxylase | −2.40 |
| ACSL4 | Acyl-CoA synthetase long-chain family member 4 | −2.18 |
aThese genes were also significantly down regulated in MDA-MB-231 treated with 10 mM metformin at 5 mM glucose