Table 3.
115F Genes down regulated by metformin and altered by miR-193
| Gene symbol | RefSeq | Fold‐change (g5 met vs. g5) | p value (g5 met vs. g5) | Prediction algorithm | Description |
|---|---|---|---|---|---|
| AFAP1‐AS | NR_026892 | −2.89766 | 1.61E‐06 | MiRanda | AFAP1 antisense RNA (non‐protein coding) |
| ARPC4 | NM_005718 | −2.06384 | 5.77E‐05 | MiRanda | Actin-related protein 2/3 complex, subunit 4, 20 kDa |
| CCDC71 | NM_022903 | −2.01874 | 0.0025781 | MiRanda | Coiled‐coil domain containing 71 |
| CCM2 | NM_031443 | −2.18803 | 1.50E‐06 | MiRanda | Cerebral cavernous malformation 2 |
| CLSTN1 | NM_001009566 | −2.1818 | 2.83E‐06 | Target Scan | Calsyntenin 1 |
| CNOT6 | NM_015455 | −2.25598 | 4.71E‐07 | Target Scan | CCR4‐NOT transcription complex, subunit 6 |
| CREB3L4 | NM_130898 | −3.35141 | 2.39E‐05 | MiRanda | cAMP responsive element binding protein 3‐like 4 |
| FASN | NM_004104 | −8.19682 | 1.75E‐08 | MiRanda | Fatty acid synthase |
| FEN1 | NM_004111 | −2.42731 | 7.58E‐08 | MiRanda | Flap structure‐specific endonuclease 1 |
| HN1L | NM_144570 | −2.40156 | 1.10E‐07 | Leivonen et al. 2011 | Hematological and neurological expressed 1‐like |
| HNRNPUL2 | NM_001079559 | −2.55145 | 7.07E‐09 | Target Scan | Heterogeneous nuclear ribonucleoprotein U‐like |
| IDI1 | NM_004508 | −3.94434 | 1.34E‐10 | Target Scan | Isopentenyl‐diphosphate delta isomerase 1 |
| IGSF3 | NM_001542 | −2.20126 | 9.90E‐06 | Leivonen et al. 2011 | Immunoglobulin superfamily, member 3 |
| IVD | NM_002225 | −3.21389 | 5.95E‐06 | MiRanda | Isovaleryl‐CoA dehydrogenase |
| KIT | NM_000222 | −3.11623 | 7.14E‐06 | MiRanda | Kit Hardy‐Zuckerman 4 feline sarcoma viral oncogene homologue |
| KRT19 | NM_002276 | −2.18542 | 5.94E‐07 | Leivonen et al. 2011 | Keratin 19 |
| LETM1 | NM_012318 | −2.16657 | 1.13E‐05 | Leivonen et al. 2011 | Leucine zipper‐EF‐hand-containing transmembrane protein 1 |
| MAP3K11 | NM_002419 | −2.50877 | 5.11E‐06 | MiRanda | Mitogen‐activated protein kinase kinase kinase 11 |
| MRPL28 | NM_006428 | −2.76247 | 7.05E‐06 | MiRanda | Mitochondrial ribosomal protein L28 |
| MUC1 | NM_001018016 | −3.7317 | 1.29E‐06 | MiRanda | Mucin 1, cell surface associated |
| NCAPD2 | NM_014865 | −2.0363 | 5.16E‐07 | Leivonen et al. 2011 | Non‐SMC condensin I complex, subunit D2 |
| NSDHL | NM_015922 | −2.25004 | 1.65E‐06 | Leivonen et al. 2011 | NAD(P)-dependent steroid dehydrogenase‐like |
| ODC1 | NM_002539 | −2.25215 | 6.14E‐07 | MiRanda | Ornithine decarboxylase 1 |
| QPRT | NM_014298 | −2.19681 | 2.52E‐05 | MiRanda | Quinolinate phosphoribosyltransferase |
| RBM14 | NM_006328 | −3.15718 | 5.21E‐07 | MiRanda | RNA binding motif protein 14 |
| RFT1 | NM_052859 | −2.03807 | 0.0002474 | Target Scan | RFT1 homologue (S. cerevisiae) |
| SCNN1A | NM_001038 | −2.86166 | 1.56E‐06 | MiRanda | sodium channel, non-voltage‐gated 1 alpha |
| SDF2L1 | NM_022044 | −2.11541 | 9.90E‐05 | MiRanda | Stromal cell‐derived factor 2‐like 1 |
| SH3TC2 | NM_024577 | −2.21405 | 0.0001689 | MiRanda | SH3 domain and tetratricopeptide repeats 2 |
| SLC23A2 | NM_005116 | −2.12693 | 0.00058 | Target Scan | Solute carrier family 23 (nucleobase transporters), member 2 |
| SLC39A7 | NM_006979 | −2.54712 | 2.56E‐06 | MiRanda | Solute carrier family 39 (zinc transporter), member 7 |
| ST6GALNAC2 | NM_006456 | −2.15331 | 7.38E‐05 | Leivonen et al. 2011 | ST6 (alpha‐N‐acetyl‐neuraminyl‐2,3‐beta‐galactosyl‐1,3)‐N‐ac |
| SURF4 | NM_033161 | −2.21445 | 2.40E‐08 | Leivonen et al. 2011 | Surfeit 4 |
| TM7SF2 | NM_003273 | −3.63654 | 1.69E‐08 | Leivonen et al. 2011 | Transmembrane 7 superfamily member 2 |
| TMED2 | NM_006815 | −2.05481 | 5.36E‐06 | MiRanda | Transmembrane emp24 domain trafficking protein 2 |
| TXLNA | NM_175852 | −2.08624 | 5.46E‐06 | Leivonen et al. 2011 | Taxilin alpha |
| WDR82 | NM_025222 | −2.57578 | 1.34E‐05 | Target scan | WD repeat domain 82 |