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. Author manuscript; available in PMC: 2015 Sep 15.
Published in final edited form as: Biometrics. 2009 Jul 23;66(2):541–548. doi: 10.1111/j.1541-0420.2009.01297.x

Figure 1.

Figure 1

Scenarios in the simulation study for the multiple myeoloma trial. The horizontal and vertical axes are dose and average toxicity score, respectively. The ATS ≡ 0.25 is represented by the horizontal dotted line. True ATS’s for the low risk group (40 < GFR ≤ 60 mL/min), moderate risk group (20 < GFR ≤ 40 mL/min), and high risk group (GFR ≤ 20 mL/min) are represented by a circle, triangle, and square, respectively. Table 1: Simulation results using the proposed design for dose finding with risk groups. For each scenario we provide the true ATS by risk group (italicized numbers in table) and report the correct selection probabilities and the average number of patients per dose for each risk group.