Table 2.

Simulation results using the M-CRM for dose finding with risk groups. For each scenario we provide the true ATS by risk group (italicized numbers in table) and report the correct selection probabilities and the average number of patients per dose for each risk group.

Selection percentage for each dose/risk-group combination (Average # of Patients)
Dose
Scen	Risk Grp	1	2	3	4	None
1	1	0.07	0.11	0.18	0.25
		0.1 (3.5)	11.2 (5.5)	40.9 (7.1)	47.5 (4.8)	0.3
	2	0.11	0.18	0.25	—
		5.4 (4.6)	33.9 (6.4)	58.0 (6.6)	— (—)	2.7
	3	0.14	0.21	—	—
		10.6 (4.5)	82.3 (6.8)	—(—)	—(—)	7.1
2	1	0.01	0.01	0.03	0.38
		0.0 (3.0)	0.0 (3.0)	28.6 (4.7)	71.4 (10.3)	0
	2	0.01	0.01	0.38	—
		0.0 (3.0)	22.8 (4.5)	77.2 (10.5)	— (—)	0
	3	0.01	0.38	—	—
		25.1 (4.4)	74.9 (7.6)	—(—)	—(—)	0
3	1	0.08	0.1	0.25	0.35
		0.1 (3.7)	16.5 (6.5)	68.0 (8.5)	15.4 (2.4)	0
	2	0.1	0.21	0.35	—
		5.1 (4.7)	53.6 (7.8)	38.7 (5.0)	— (—)	2.6
	3	0.1	0.25	—	—
		14.6 (4.5)	82.3 (7.2)	—(—)	—(—)	3.1
4	1	0.06	0.17	0.24	0.31
		0.5 (3.7)	31.7 (8.2)	48.7 (6.8)	19.1 (2.3)	0
	2	0.17	0.27	0.31	—
		32.8 (8.1)	39.7 (6.3)	22.7 (2.9)	— (—)	4.8
	3	0.25	0.31	—	—
		37.5 (6.2)	40.2 (3.9)	—(—)	—(—)	22.3
5	1	0.21	0.38	0.4	0.4
		63.7 (13)	27.1 (6.8)	1.8 (0.4)	0.0 (0.0)	7.4
	2	0.24	0.38	0.4	—
		77.5 (13)	15.0 (4.0)	1.3 (0.3)	— (—)	6.2
	3	0.36	0.38	—	—
		41.8 (7.1)	10.4 (1.5)	—(—)	—(—)	47.8
6	1	0.47	0.49	0.51	0.52
		6.3 (7.7)	0.0 (0.4)	0.0 (0.0)	0.0 (0.0)	93.7
	2	0.48	0.5	0.52	—
		7.9 (6.7)	0.2 (0.3)	0.0 (0.0)	— (—)	91.9
	3	0.49	0.51	—	—
		14.1 (5.5)	0.2 (0.3)	—(—)	—(—)	85.7