Table 1.
Anthropometric, clinical and biochemical features of 168 patients with type 2 diabetes and correlation coefficients of annual changes in estimated glomerular filtration rate and coefficients of variation of HbA1c
| Mean ± SD or n, % | ⊿eGFR | CV-HbA1c | |||||
|---|---|---|---|---|---|---|---|
| Male sex (n, %) | 90 | , | 54 | −0.013 | −0.17 | * | |
| Smokers (n, %) | 58 | , | 34 | −0.159 | * | 0.111 | |
| Age (years) | 62.3 | ± | 10 | 0.037 | −0.145 | ||
| BMI (kg/m2) | 24.2 | ± | 3.6 | −0.048 | 0.045 | ||
| Waist circumference (cm) | 86.9 | ± | 9.9 | −0.108 | 0.017 | ||
| Duration of diabetes (years) | 9.9 | ± | 7.3 | −0.047 | −0.009 | ||
| Treatment of | |||||||
| diabetes; diet/OHA/insulin (%) | 31/51/18 | −0.078 | 0.201 | ** | |||
| hypertension; CCB/RASi/diuretics (%) | 34/41/5 | −0.076 | −0.044 | ||||
| HbA1c (%) | 7.0 | ± | 0.8 | −0.050 | 0.343 | *** | |
| Fasting PG (mg/dL) | 125 | ± | 22 | −0.012 | 0.299 | *** | |
| Post-breakfast PG (mg/dL) | 154 | ± | 49 | 0.047 | 0.229 | ** | |
| CV-HbA1c (%) | 7.0 | ± | 6.4 | −0.187 | * | 1 | |
| CV-Fasting PG (%) | 14.1 | ± | 9.3 | −0.127 | 0.473 | *** | |
| CV-Post-breakfast PG (%) | 21.9 | ± | 11.0 | −0.152 | 0.190 | * | |
| Total cholesterol (mg/dL) | 188 | ± | 21 | 0.048 | 0.025 | ||
| LDL cholesterol (mg/dL) | 111 | ± | 22 | 0.0004 | 0.096 | ||
| HDL cholesterol (mg/dL) | 56 | ± | 15 | 0.128 | −0.202 | ** | |
| Fasting TG (mg/dL) | 115 | ± | 51 | −0.161 | * | 0.187 | * |
| Post-breakfast TG (mg/dL) | 145 | ± | 64 | −0.164 | * | 0.235 | ** |
| Serum creatinine (mg/dL) | 0.75 | ± | 0.2 | −0.042 | 0.084 | ||
| eGFR (mL/min/1.73m2) | 76 | ± | 16 | −0.111 | 0.165 | * | |
| ⊿eGFR (mL/min/1.73m2/year) | −1.05 | ± | 3.39 | 1 | −0.187 | * | |
| Uric acid (mg/dL) | 5.2 | ± | 1.3 | −0.125 | 0.033 | ||
| Systolic BP (mmHg) | 128 | ± | 12 | −0.014 | −0.051 | ||
| CV-Systolic BP (%) | 8 | ± | 22 | −0.035 | 0.098 | ||
| Diastolic BP (mmHg) | 72 | ± | 1 | 0.003 | 0.112 | ||
| Urinary ACR (mg/g) | 84 | ± | 322 | −0.208 | ** | 0.067 | |
| log ACR | 1.30 | ± | 0.6 | −0.243 | ** | 0.072 | |
OHA oral hypoglycemic agents, CCB calcium channel blockers, RASi renin-angiotensin system inhibitors, PG; plasma glucose, CV; coefficient of variation, eGFR; estimated glomerular filtration rate, ⊿eGFR; annual changes in eGFR, BP blood pressure, ACR albumin/creatinine ratio, *; p < 0.05,**; p < 0.01,***; p < 0.001