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. 2015 Sep 15;12(9):e1001875. doi: 10.1371/journal.pmed.1001875

Table 3. Violent crime convictions in 2006–2009 in individuals treated with SSRI medication compared to non-treatment periods in the same person stratified by sex, age, dose, and medication type using stratified Cox regression models.

Characteristic HR (95% CI) p-Value Number of Events Absolute Risk, Percent (n)
Sex
Males 1.22 (1.09–1.37) <0.001 6,905 2.1 (5,020)
Females 1.21 (0.94–1.56) 0.141 1,687 0.3 (1,418)
Age
15 to 24 y 1.43 (1.19–1.73) <0.001 2,798 3.0 (2,081)
25 to 34 y 1.20 (0.95–1.52) 0.125 1,966 1.6 (1,454)
35 to 44 y 1.06 (0.83–1.35) 0.666 1,905 1.2 (1,457)
45 y and over 1.07 (0.84–1.35) 0.594 1,918 0.3 (1,446)
Sex and age: males
15 to 24 y 1.40 (1.13–1.73) 0.002 2,169 6.6 (1,540)
25 to 34 y 1.16 (0.90–1.49) 0.265 1,629 3.6 (1,173)
35 to 44 y 1.11 (0.85–1.46) 0.428 1,538 2.8 (1,133)
45 y and over 0.97 (0.75–1.25) 0.792 1,566 0.8 (1,174)
Sex and age: females
15 to 24 y 1.75 (1.08–2.84) 0.023 629 1.2 (541)
25 to 34 y 1.67 (0.88–3.18) 0.119 337 0.5 (281)
35 to 44 y 0.76 (0.42–1.41) 0.388 367 0.4 (324)
45 y and over 1.80 (0.97–3.32) 0.062 352 0.1 (272)
Cumulative SSRI exposure
Low SSRI exposure 1.27 (1.10–1.47) 0.001 896 n/a
Moderate SSRI exposure 1.11 (0.96–1.28) 0.163 1,038 n/a
High SSRI exposure 1.06 (0.88–1.29) 0.528 562 n/a
Type of SSRI medication
Fluoxetine 1.16 (0.88–1.52) 0.287 1,276 1.4 (916)
Citalopram 1.14 (0.96–1.36) 0.130 3,088 0.6 (2,292)
Paroxetine 1.24 (0.87–1.77) 0.227 784 1.2 (577)
Sertraline 1.22 (1.02–1.46) 0.031 3,003 1.0 (2,241)
Escitalopram 1.02 (0.77–1.34) 0.904 1,446 1.2 (1,051)

Analyses excluded individuals with only one dispensed prescription. There were too few individuals for separate analyses of fluvoxamine.

n/a, not applicable.