Table 3. Violent crime convictions in 2006–2009 in individuals treated with SSRI medication compared to non-treatment periods in the same person stratified by sex, age, dose, and medication type using stratified Cox regression models.
Characteristic | HR (95% CI) | p-Value | Number of Events | Absolute Risk, Percent (n) |
---|---|---|---|---|
Sex | ||||
Males | 1.22 (1.09–1.37) | <0.001 | 6,905 | 2.1 (5,020) |
Females | 1.21 (0.94–1.56) | 0.141 | 1,687 | 0.3 (1,418) |
Age | ||||
15 to 24 y | 1.43 (1.19–1.73) | <0.001 | 2,798 | 3.0 (2,081) |
25 to 34 y | 1.20 (0.95–1.52) | 0.125 | 1,966 | 1.6 (1,454) |
35 to 44 y | 1.06 (0.83–1.35) | 0.666 | 1,905 | 1.2 (1,457) |
45 y and over | 1.07 (0.84–1.35) | 0.594 | 1,918 | 0.3 (1,446) |
Sex and age: males | ||||
15 to 24 y | 1.40 (1.13–1.73) | 0.002 | 2,169 | 6.6 (1,540) |
25 to 34 y | 1.16 (0.90–1.49) | 0.265 | 1,629 | 3.6 (1,173) |
35 to 44 y | 1.11 (0.85–1.46) | 0.428 | 1,538 | 2.8 (1,133) |
45 y and over | 0.97 (0.75–1.25) | 0.792 | 1,566 | 0.8 (1,174) |
Sex and age: females | ||||
15 to 24 y | 1.75 (1.08–2.84) | 0.023 | 629 | 1.2 (541) |
25 to 34 y | 1.67 (0.88–3.18) | 0.119 | 337 | 0.5 (281) |
35 to 44 y | 0.76 (0.42–1.41) | 0.388 | 367 | 0.4 (324) |
45 y and over | 1.80 (0.97–3.32) | 0.062 | 352 | 0.1 (272) |
Cumulative SSRI exposure | ||||
Low SSRI exposure | 1.27 (1.10–1.47) | 0.001 | 896 | n/a |
Moderate SSRI exposure | 1.11 (0.96–1.28) | 0.163 | 1,038 | n/a |
High SSRI exposure | 1.06 (0.88–1.29) | 0.528 | 562 | n/a |
Type of SSRI medication | ||||
Fluoxetine | 1.16 (0.88–1.52) | 0.287 | 1,276 | 1.4 (916) |
Citalopram | 1.14 (0.96–1.36) | 0.130 | 3,088 | 0.6 (2,292) |
Paroxetine | 1.24 (0.87–1.77) | 0.227 | 784 | 1.2 (577) |
Sertraline | 1.22 (1.02–1.46) | 0.031 | 3,003 | 1.0 (2,241) |
Escitalopram | 1.02 (0.77–1.34) | 0.904 | 1,446 | 1.2 (1,051) |
Analyses excluded individuals with only one dispensed prescription. There were too few individuals for separate analyses of fluvoxamine.
n/a, not applicable.