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. 2015 Sep 15;10(9):e0137397. doi: 10.1371/journal.pone.0137397

Fig 1. CDKN3 gene expression in normal cervical epithelium and cervical cancer samples.

Fig 1

The expression of cyclin-dependent kinase inhibitor 3 (CDKN3) was measured by RT-qPCR in 25 normal healthy cervix samples and 134 cervical cancer (CC) samples positive for human papillomavirus (HPV)16 (n = 90) or for other HPV types (n = 44), including 18, 31, 33, 35, 45, 51, 52, 53, 58, 59, and 68. (A) Intensity of gene expression, expressed in Log2 values, in box plots. The upper and lower boundaries of the boxes represent the 75th and 25th percentiles, respectively. The black and dotted lines within the boxes represent the median and mean values, respectively, and the whiskers represent the minimum and maximum values that lie within 1.5x the interquartile range from the end of the box. Values outside this range are represented by black circles. The fold change (FC) was calculated by dividing the median of each CC group by the median of the control group. Statistical differences between groups were calculated using the nonparametric Mann-Whitney U test. (B) Frequency (%) distribution of CDKN3 FCs, which were calculated in each tumor considering the median of the control group.