Table 2.

Disease	Factors Associated with Sensitivity	Factors Associated with Resistance
Head and neck cancer	Accelerated radiation fractionation Acneiform rash (cetuximab) Oropharynx primary	HPV negative tumor Smoker Non-oropharynx primary
Nonsmall cell lung cancer	EGFR mutation: exon 19 and 12 (L858R, L861), exon 18 (G719X, G719), exon 20 (S7681) KRAS wild type EGFR overexpression Non-squamous cell histology Non-smoker Asian heritage Female sex	EGFR T790M mutation EGFR exon 20 insertion KRAS mutation Squamous cell carcinoma MET amplification/overexpression Epithelial to mesenchymal transition
Colorectal cancer	RAS wild type BRAF wild type Increased EGFR gene copy number	KRAS mutation NRAS mutation BRAF mutation MET amplification/overexpression HER2 amplification/overexpression EGFR mutation in cetuximab binding domain (rare)