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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Semin Arthritis Rheum. 2015 Apr 30;45(2):220–228. doi: 10.1016/j.semarthrit.2015.04.014

Table 2.

Typical inflammation-related factors of bone loss [recently reviewed in. (6–11)].

inflammation-related factor
CD4+ T cells* via TNF, RANKL, IFN-γ, LIGHT, IL-15, IL-17
CD8+ T cells* via TNF, RANKL
macrophages via TNF, IL-1β, IL-6
neutrophils via reactive oxygen species
immunologically stimulated bone stromal cells via RANKL and M-CSF
*

In contrast, T regulatory cells and B cells suppress bone resorption in ovariectomy-induced bone loss and in models of rheumatoid arthritis by secreting anti-osteoclastogenic factors like osteoprotegerin.