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. Author manuscript; available in PMC: 2015 Sep 15.
Published in final edited form as: JAMA Neurol. 2015 Sep 1;72(9):1029–1042. doi: 10.1001/jamaneurol.2015.1285

Figure 2. Longitudinal Change in Cerebrospinal Fluid Biomarkers Visinin-Like Protein 1 (VILIP-1) and Chitinase-3-Like Protein 1 (YKL-40) During Middle Age.

Figure 2

Estimated group slopes and within-person changes for VILIP-1 (A) and YKL-40 (B) are shown in the 3 age bins for APOE ε4 noncarriers (top graph of each panel; n = 108 participants) and ε4 carriers (bottom graph of each panel; n = 61 participants). Annual slopes have been extrapolated to 9 years, and each slope begins at the mean baseline biomarker value from individuals in each age bin. Group baseline values and slopes represent the estimates reported in Table 1 and Table 2, respectively, for the different cohorts defined by baseline age in which biomarker concentrations were regressed on time from study entry.

aSlope significantly different from 0 (P < .05).

bSlope significantly different between APOE ε4 groups within a given age group (P < .05).