Fig. 2.

DnaJA2 is more dependent on EEVD(Hsp70) than Ydj1 in protein refolding. (A, B) 6M GuHCl denatured luciferase was diluted into refolding buffer containing (A) Hsp72/DnaJA2 and (B) Ssa1/DnaJA2 or Ydj1. Aliquots were taken at the indicated times and luciferase activity determined. Activity of non-denatured luciferase was set at 100%. (C) 6M urea denatured luciferase was diluted into refolding buffer containing Hsp72/DnaJB1or DnaJA2 in addition to the nucleotide exchange factor Apg2 and Hsp104. Aliquots were taken at the indicated times and luciferase activity was determined (non-denatured luciferase: 100%).