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The association between higher HOMA-IR and lower regional FDG-PET uptake in 150 late middle-aged adults (p < .05 FWE). Results are displayed on representative cross-sections for temporal, parietal, and frontal regions. Uptake values were adjusted by the following covariates: age, sex, family history status, APOE-ε4 genotype, and glucose metabolism in the reference region. The color bar depicts t-values. Brains are oriented in neurological space. FWE = family-wise error corrected.
