The association between left medial temporal FDG-PET uptake predicted by the HOMA-IR analysis and cognitive function factors. (A–B) Higher FDG-PET in left medial temporal lobe (MTL), as a function of lower HOMA-IR, predicted better performance on the verbal learning and immediate memory factors. (C–D) Left MTL was not associated with the working memory factor, but was associated with the speed and flexibility factor. The FDG-PET signal was adjusted by the FDG reference region, age, sex, APOE-ε4 genotype, family history status, and HOMA-IR. * = p < .05; *** = p < .001. .