Table 1. Patient demographics.
| Variables | NAFLD (N=68) | Non-NAFLD (N=523) | P value |
|---|---|---|---|
| Age, mean | 62.5 | 59.5 | <0.001 |
| Male gender [%] | 42 [62] | 356 [68] | 0.30 |
| BMI, mean | 31.6 | 29.1 | <0.001 |
| Obese (BMI ≥30) | 39 [57] | 153 [29] | <0.001 |
| Race/ethnicity [%] | 0.12 | ||
| Non-Hispanic White | 46 [68] | 270 [52] | |
| Hispanic | 9 [13] | 105 [20] | |
| African American | 3 [4] | 35 [7] | |
| Asian | 4 [6] | 42 [8] | |
| Other/unknown | 6 [9] | 71 [14] | |
| Etiology of liver disease [%] | — | ||
| NAFLD | 68 [100] | — | |
| HCV | — | 266 [51] | |
| HBV | — | 37 [7] | |
| Alcohol | — | 113 [22] | |
| AIH/PSC/PBC | — | 57 [11] | |
| Other | — | 50 [10] | |
| HCC [%] | 19 [28] | 168 [32] | 0.49 |
| Medical comorbidities [%] | |||
| Metabolic syndrome | 20 [29] | 33 [6] | <0.001 |
| Diabetes mellitus | 48 [71] | 145 [28] | <0.001 |
| Hypertension | 31 [46] | 175 [33] | 0.05 |
| Coronary artery disease | 21 [31] | 48 [9] | <0.001 |
| Significant alcohol use [%] | <0.001 | ||
| Recent | 0 [0] | 9 [2] | |
| Former | 6 [9] | 184 [35] | |
| Never | 62 [91] | 330 [63] | |
| Tobacco use [%] | 0.02 | ||
| Current | 3 [4] | 56 [11] | |
| Former | 19 [28] | 202 [39] | |
| Never | 46 [68] | 265 [51] | |
| Intravenous drug use [%] | 0.01 | ||
| Current | 0 [0] | 1 [0.2] | |
| Former | 2 [3] | 86 [16] | |
| Never | 66 [97] | 436 [83] | |
| Listed for liver transplant [%] | 53 [78] | 420 [80] | 0.65 |
| Transplanted [%] | 37 [54] | 260 [50] | 0.47 |
| MELD, mean | 15.1 | 14.5 | 0.58 |
| CTP score, median | 8 | 8.1 | 0.89 |
| CTP class [%] | 0.29 | ||
| A | 18 [26] | 161 [31] | |
| B | 35 [51] | 217 [41] | |
| C | 15 [22] | 145 [28] | |
| Portal hypertension [%] | |||
| Esophageal varices | 45 [66] | 321 [61] | 0.44 |
| Hepatic encephalopathy | 36 [53] | 276 [53] | 0.98 |
| Ascites | 39 [57] | 295 [56] | 0.88 |
| Spontaneous bacterial peritonitis | 3 [4] | 16 [3] | 0.55 |
| Laboratory values*, mean | |||
| Albumin (g/dL) | 3.3 | 3.2 | 0.86 |
| Hemoglobin (g/dL) | 11.6 | 11.9 | 0.26 |
| INR | 1.4 | 1.4 | 0.54 |
| AFP (ng/mL) | 92.6 | 54 | 0.34 |
| Creatinine (mg/dL) | 1.3 | 1.2 | 0.4 |
| Bilirubin (mg/dL) | 3.6 | 3.7 | 0.96 |
| Platelets (103/uL) | 101.1 | 111.8 | 0.23 |
*, all laboratory values are at the time of presentation for listing; NAFLD, non-alcoholic fatty liver disease; BMI, body mass index; INR, international normalized ratio; AFP, alpha fetoprotein; MELD, model for end stage liver disease; CTP, child turcotte pugh score.