Table 1. ALDH2 protein production in the oesophagus of Aldh2 +/+ and Aldh2 –/– mice treated with or without ethanol drinking.
Groups | ALDH2 level | |
---|---|---|
Negative | Positive | |
Aldh2+/+ mice | ||
Water | 10 | 0 |
Ethanol | 4 | 6 |
Aldh2–/– mice | ||
Water | 10 | 0 |
Ethanol | 10 | 0 |
We defined positive of ALDH2 protein levels when more than 50% of the cells were stained with anti-ALDH2 antibody in the basal and parabasal layers of the oesophageal epithelium. Ethanol drinking induced ALDH2 in the oesophageal epithelium in 6 out of 10 Aldh2+/+ mice, whereas there was no induction in the water group of Aldh2+/+ mice (p = 0.011 by Fisher’s exact test).