Figure 2.

Mechanical properties of K562 leukemia cells: entry timescales with applied pressure and maximum cell deformation according to a power law. (a) Scatter plot of entry time versus pressure data for a typical experiment. The variance in pressure from 100 to 800 Pa arises from a combination of slow manual changes of the externally applied pressure, and stochastic pressure fluctuations due to different clogging configurations. Each marker represents the data from an individual cell. As a guide to the eye, the local density of data points is indicated by the marker color. (Solid markers) Geometric mean of ∼300 cells binned according to pressure. (Solid line) Fit of Eq. 3 to the nonbinned data. (b) Scatter plot of entry time versus maximum cell deformation (${\epsilon }_{\text{max}}$). Only cells from (a) that experienced an average pressure of 358 ± 25 Pa (mean ± SD) are shown. (Solid markers) Geometric mean of 70 cells binned according to cell deformation. (Solid line) Fit of Eq. 3 to the nonbinned data. To see this figure in color, go online.