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The effect of traumatic brain injury (TBI) on intracranial pressure (ICP) in different groups (n = 7 in each group). The data are represented as mean ± SEM. ***P < 0.001; at 4 and 24 h after TBI for TBI vs. sham, ### P < 0.001; at 4 and 24 h after TBI for TBI + E2 vs TBI and TBI + OIL groups (A). ***P < 0.001; at 4 and 24 h after TBI for TBI + ICI + E2 vs TBI + E2 and TBI + DMSO + E2 (B). E2 (estradiol), ICI (ICI 182,780).
