Table 4.
Anxiety scale relationship with MECP2 mutation severity
| Mild (n = 26) | Severe (n = 46) | Mutation differences | |||||
|---|---|---|---|---|---|---|---|
| N | Median | SD | Median | SD | aMann-Whitney U | aAsymp. sig (two-tailed) | |
| CSS | 51 | 18.00 | 5.47 | 22.00 | 5.54 | 175.00* | 0.009 |
| RSBQ | |||||||
| Fear/anxiety | 72 | 5.00 | 2.11 | 4.00 | 2.01 | 504.50 | 0.267 |
| ADAMS | |||||||
| Social avoidance | 72 | 4.00 | 3.29 | 4.00 | 3.69 | 515.50 | 0.330 |
| General anxiety | 71 | 7.00 | 4.32 | 5.00 | 4.80 | 377.00 | 0.013 |
| ABC-C | |||||||
| Lethargy/social withdrawal | 47 | 9.50 | 6.46 | 6.50 | 4.47 | 208.00 | 0.207 |
| Social avoidance | 47 | 1.50 | 2.79 | 0.00 | 1.34 | 208.50 | 0.179 |
In bold, significant and trend-level p values
*Adjusted for multiple [5] comparisons (excluding CSS) with Bonferroni corrections for the five anxiety-related measures, adjusted p = 0.01
aGrouping mild vs. severe MECP2 mutation