Table 2.

Main studies evaluating the relationships between ACE I/D genotypes and response to ARA therapy in diabetic renal disease

	Andersen et al. (46), 2003	Andersen et al. (47), 2002	Parving et al. (50), 2008	Haneda et al. (48), 2004
Ethnicity	White	White	White	Asian
Type of diabetes	I	I	II	II
No. of patients	54	54	1435	126
Follow-up (yr)	3	0.33	3.4	0.25
Patient characteristics	Hypertension with persistent albuminuria	Hypertension with persistent albuminuria	Proteinuria	Proteinuria
Baseline characteristics of genotype groups	Comparable	Comparable	Comparable (but BMI and race)	Comparable
Treatment in genotype groups	Comparable	Comparable	?	?
Adjustments for relevant covariates	No	No	Yes	?
Effect of ARA therapy	Comparable proteinuria reduction and GFR decline in II and DD	Comparable albuminuria reduction in II (55%) and DD (46%)	Risk reduction for ESKD: DD, 50.1%; ID, 30.5%; II, 3.1%	No interaction between genotype and albuminuria reduction

?, insufficient information.