Table 3. Substrate Scope of Aziridination with P-I263F-A328V-L437V Showing Productivity and Selectivity for Each Producta.
Reactions were carried out with whole cells expressing P-I263F-A328V-L437V under anaerobic conditions, with 2.5 mM tosyl azide and 7.5 mM olefin.
% ee determined as (S – R)/(S + R). Absolute configurations were assigned based on analogy to 6. rac = racemic.