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T-VISA-PEA-15 nanoparticles have no systemically acute toxicity compared with CMV-PEA-15 in immunocompetent mice.
(A and B) Kaplan-Meier survival analysis of female BALB/c mice who were treated with single doses of 100 μg or 50 μg plasmid in a liposomal complex via the tail vein. (C, D, and E) Kinetics serum level of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and blood creatinine (CRE) in mice after a single dose of 50 μg plasmid injection. Asterisk, P < 0.05.
