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. Author manuscript; available in PMC: 2016 Jan 28.
Published in final edited form as: Cancer Lett. 2014 Oct 7;356(2 0 0):374–381. doi: 10.1016/j.canlet.2014.09.033

Fig.6.

Fig.6

Diagrammatic sketch of the T-VISA-PEA-15 system targeting to breast cancer.

The T-VISA-PEA-15 system involves a series of steps in human breast cancer: Firstly, the hTERT promoter drives the GAL4-VP2 fusion protein specifically expression in breast tumor and then open target gene PEA-15 mRNA transcripts. Afterwards, the PEA-15 mRNA transcripts enhance and prolong expression duration of PEA-15 protein, which can sequesters extracellular signal-regulated kinase (ERK) in cytoplasm, thereby leading to apoptosis of breast cancer cells. However, there’s little non-specificity gene expression in normal cells for the activity of hTERT promoter is very lower, thereafter, normal cells survival.