. Author manuscript; available in PMC: 2016 Oct 1.

Published in final edited form as: Surg Oncol Clin N Am. 2015 Jul 27;24(4):795–832. doi: 10.1016/j.soc.2015.06.008

Table 1.

Basic facts about the different endocrine neoplasia familial syndromes

Fanilial Endocrine Syndrome	Chromosome	Gene	Pattern of inheritance	Glands Involved	Extraglandular manifestations	Cause of death
MEN-1	11	Menin	Autosomal dominant	Parathyroid Pancreas Pituitary Thyroid Adrenal	Bronchus Thymus Stomach Lipomas Skin tumors	Pancreatic NET, Bronchial or thymic NET
MEN-2a	10	RET	Autosomal dominant	Thyroid Adrenal Parathyroid	None	MTC
MEN-2b (MEN-3)	10	RET	Autosomal dominant	Thyroid Adrenal	Marfanoid habitus, Mucosal neuromas, Corneal nerve hypertrophy, Intestinal ganglioneruomatosis.	MTC
FMTC	10	RET	Autosomal dominant	Thyroid	None	Natural causes
MEN-4	12	CDKN1B/p27Kip1	Autosomal dominant	Parathyroid GEP pituitary	none	unclear