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. 2014 Dec 15;36(1):37–43. doi: 10.1038/aps.2014.117

Figure 2.

Figure 2

FXR and anti-liver carcinogenesis. FXR suppresses liver carcinogenesis via several diverse mechanisms: 1) FXR maintains the normal liver homeostasis and metabolism of BAs, glucose, and lipid. 2) FXR promotes liver regeneration and repair after injury; 3) FXR suppresses hepatic inflammation; 4) FXR enhances hepatocyte cell survival; and 5) FXR increases the expression of some tumor suppressor genes and represses the transcription of several oncogenes.