BUN and creatinine levels, and the ratio of urine protein to creatinine prior to and at 72 h after acute kidney IR injury (n=8 for each group). (A) Serum blood urea nitrogen (BUN) level prior to IR procedure (ie, at baseline), P>0.05. (B) Serum BUN level at 72 h after IR procedure, cP<0.01 vs other groups with different symbols. (C) Serum creatinine level prior to IR procedure, P>0.05. (D) Serum creatinine level at 72 h after IR procedure, cP<0.01 vs other groups with different symbols. (E) Urine amount prior to IR procedure, P>0.05. (F) Urine amount at 72 h after the procedure, cP<0.01 vs other groups with different symbols. (G) The ratio of urine protein to creatinine prior to IR procedure, P>0.05. (H) The ratio of urine protein to creatinine at 72 h after IR procedure, cP<0.01 vs other groups with different symbols. All statistical analyses using one-way ANOVA, followed by Bonferroni multiple comparison post hoc test. SC, sham control; KIR, kidney ischemia reperfusion; Sita, sitagliptin.