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. 2015 Aug 1;26(15):2755–2768. doi: 10.1091/mbc.E14-06-1105

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© 2015 Nimlamool et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 2: — VEGF induces a rapid reorganization of lateral junctional membranes and internalization of GJs into annular GJs. PAECs were processed untreated or after treatment with VEGF for 5 and 15 min and examined by thin-section electron microscopy. (A–C) GJs with distinctive pentalaminar-striped staining pattern (labeled with arrows), in general small in size, as characteristic for these endogenously Cx43-expressing cells, were detectable in untreated cells. (D) Cells in the 5-min VEGF-treated samples largely exhibited undulating lateral membranes suggestive of GJs in the process of internalization (arrows). (E, F) Cytoplasmic AGJs with vesicular, double-membrane GJ morphology (arrowheads) were also detected, especially in the VEGF-treated cells. On some AGJs, a patchy protein coat similar in appearance to clathrin coats was detected (open arrowhead in F, enlarged on the right). M, mitochondria; N, cell nucleus; PMs, lateral plasma membranes.