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. 2015 Aug 1;26(15):2755–2768. doi: 10.1091/mbc.E14-06-1105

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© 2015 Nimlamool et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 8: — Schematic representation illustrating VEGF-induced, MAPK/PKC-mediated GJ internalization in PAECs. VEGF binds to, phosphorylates, and activates VEGF receptors, receptor tyrosine kinases located in the plasma membranes of endothelial cells. Activated VEGF-receptor actuates MAPK and PKC signaling cascades to phosphorylate Cx43 at Ser-255, Ser-262, Ser-279/282, and Ser-368. Phosphorylated Cx43 can then interact with and bind clathrin adaptors and clathrin to mediate GJ endocytosis.