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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Histol Histopathol. 2015 Feb 9;30(7):781–792. doi: 10.14670/HH-11-594

Figure 1.

Figure 1

Schematic of CXCR3 isoforms gene and protein sequence. CXCR3 gene mapped on human chromosome X with two exons and one intron. CXCR3-B transcript variant uses an alternate acceptor splice site at the 3’ terminal exon compared to CXCR3-A variant. This and an alternative in-frame ATG start codon result in CXCR3-B with a longer and distinct N-terminus compared to CXCR3-A. Both isoforms encode a seven-transmembrane G-protein coupling protein. TD: transmembrane domain; In-loop: intracellular loop; Ex-loop: extracellular loop.