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. Author manuscript; available in PMC: 2016 Aug 17.
Published in final edited form as: Chem Res Toxicol. 2015 Aug 6;28(8):1603–1615. doi: 10.1021/acs.chemrestox.5b00177

Table 3.

Correlation between Caffeine P450 1A2 Phenotype Activity and % of Dose of Urinary HAA Biomarker or Caffeine P450 1A2 Phenotype Activity and HAA Metabolic Ratio

Biomarkers Spearman correlations
Day 35
(n=44)		 p-value Day 49
(n=44)		 p-value Adjusted for Days 35, 49
(n=88)		 p-value
P450 1A2 & % Dose PhIP −0.25 0.10 0.20 0.20 −0.02 0.85
P450 1A2 & % Dose MeIQx −0.29 0.061 0.07 0.63 −0.08 0.49
P450 1A2 & % Dose IQx-8-COOH −0.11 0.46 0.23 0.14 0.08 0.46
P450 1A2 & % Dose 8-CH2OH-IQx −0.38 0.012 0.11 0.49 −0.10 0.34
P450 1A2 & % Dose HONH-PhIP-N2-GI −0.19 0.23 0.33 0.031 0.11 0.30
P450 1A2 & % Dose HONH-PhIP-N3-GI −0.20 0.18 0.23 0.14 0.03 0.80
P450 1A2 & MR IQx-8-COOH 0.09 0.55 0.22 0.15 0.14 0.20
P450 1A2 & MR 8-CH2OH-IQx −0.22 0.15 0.02 0.87 −0.09 0.39
P450 1A2 & MR HONH-PhIP-N2-GI 0.09 0.55 0.09 0.57 0.09 0.42
P450 1A2 & MR HONH-PhIP-N3-GI 0.03 0.83 0.01 0.97 0.01 0.96