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Treatment with tamoxifen diet results in biochemical reversal of the Shank3 protein in Reversible-Shank3GCre+ mice. Quantification and representative Western blot of whole-brain lysates showing reversal of Shank3 protein expression with C terminus antibody (JH3025) 2 weeks after administration of tamoxifen diet for 4 weeks (initiated at 8 weeks of age). Data are normalized to the β-actin control and then to the average of WT levels (N = 7). *p < 0.05.
