Figure 3.
Etomidate potentiates tonic inhibition in fl–α5 and KO mice. A–C, Spontaneous inhibitory currents recorded in CA1 pyramidal neurons of brain slices prepared from fl–α5 (A), gl–α5–KO (B), and CA1–pyr–α5–KO (C) mice, in the absence (Ctrl) and presence of etomidate (Etom; 0.5 and 1 μm). Bars above traces represent application of the noncompetitive GABAAR channel blocker PTX (100 μm). D, Summary bar plot of amplitudes (mean ± SEM) of tonic inhibition measured in the three genotypes under different conditions. **p < 0.005, ***p < 0.0005, ****p < 0.0001; n = 5–9 cells per group.