Figure 6.

miR-155 elevation increases proliferation in the DG. A, Representative images of Ki67 staining (a cell proliferation marker) in control, miR155-hi, miR155-lo, and miR155-hi-adult DG, with hematoxylin counterstaining. Arrows indicate Ki67⁺ proliferating cells. B, Quantification of Ki67⁺ cells in the DG. Total number of Ki67⁺ cells per DG was counted in at least 15 sections per group from at least 2 different animals per group and normalized by the area size. Scale bar, 100 μm, Original objective = 10×. ****p < 0.0001, ***p < 0.001, and *p < 0.05 as determined by 1-way ANOVA and Tukey post hoc. Data are shown as mean ± SEM.