Table 5.

Analysis of differentially expressed orthologs genes with popular mechanisms of aging.

Mechanisms	Genes involved
Mitochondrion	ALDH18A1, ALDOC ∗ , ARG2, BCL2L10, BID, CAPRIN2, CYP11A1 ∗ DSP, FAM136A, FEN1, GATM, ILF3, LACTB2 ∗ MTIF3, NADKD1 ∗ , P4HA1, PPP3CB, RARS2, SHMT1, TOMM34, TPP1 ∗, and USP30
Oxidation reduction and electron transport	ALDH18A1, AOX1 ∗ , CYP11A1 ∗ , FADS1 ∗ , HSD17B1, KDM1A, LDHAL6A, NARF, NELL1, P4HA1, and RETSAT ∗
Apoptosis	ALDOC ∗ , ARHGEF7, AVEN, BARD1, BCL2L10, BCLAF1, BID, BRCA1, BUB1B, CASP2, CDK1, CSE1L, DEDD, F2, GAL, HELLS, KRT8, MAEL, MMP9 ∗ , MSH2, NELL1, NPM1, SOX4, TIA1, TUBB, and TUBB2C
Immune system	AOX1 ∗ , BCL11A, CCNB2, CHD7, CHIT1 ∗ , CLEC1A ∗ , F2, GAL, GLMN, IGFBP4 ∗ , IGHE, IL1R1 ∗ , ILF2, JARID2, MASP1 ∗ , MMP9 ∗ , MSH2, OPRK1, PPP3CB, SOX4, TACC3, TCF3, THY1 ∗ , TUBB, TUBB2C, and XRCC6
DNA replication and repair	ASF1A, BARD1, BRCA1, CCNO, CHAF1A, CHEK1, DKC1, DTL, FANCE, FANCI, FEN1, GINS2, HMGA1, MCM10, MCM3, MCM5, MCM7, MORF4L1, MSH2, NASP, NEIL3, ORC6L, PAPD7, PARP1, POLD1, POLD3, PTTG1, RAD50, RAD51, RAD51C, RBM4, RFC3, RFC4, RMI2, RUVBL2, SFPQ, SSRP1, TDP1, TRIP13, TYMS, and XRCC6
Methylation	DHX9, DNMT3A, DNMT3B, FBL, FUS, HELLS, HMGA1, HNRNPD, HNRNPK, HNRNPU, HNRPDL, ILF3, MAEL, PABPC4, PRMT5, PRMT7, RAP1A ∗ , RASL10A, RHOQ ∗ , RRAS2, SFPQ, SRSF1, SUV39H2, TDRD1, TGS1, THOC4, TUBA1B, and TUBB
Reproduction	AMH, BCL2L10, CCNB1, CCNE1, CELSR2, CEP57, CHD7, CHEK1, DAZAP1, DEDD, DNMT3A, FIGLA, HIST1H1A, HSF2BP, LHX8, MAEL, MBD2, MSH2, NLRP14, NPM2, OOEP, PPAP2B ∗ , PRMT7, PTTG1, RAD51C, RPL39L, STRBP, TDRD1, TRIP13, ZP2, ZP3, and ZP4
Aging	NPM1, ENG ∗ , MSH2, FADS1 ∗, and ALDOC ∗
Telomere	DKC1, PARP1, XRCC6, and RAD50

^∗Orthologs genes upregulated in old monkey ovaries.