Table 7.

Results of functional annotation of orthologs genes downregulated in old monkey ovary compared to young and middle-aged monkey ovary.

Category	Term	Genes
Cell cycle	Cell cycle/mitosis/mitotic cell cycle/nuclear division/cell division/organelle fission	BARD1, RAD51, CDCA2, BUB1, TTK, CCNB1, PTTG1, KIF15, SUV39H2, NCAPH, NCAPG, MCM3, TACC3, OIP5, CCNB2, and AURKA
Cellular macromolecules	Macromolecular complex assembly/macromolecular complex subunit organization/protein complex biogenesis/assembly	TGS1, RAD51, TUBB2C, DNAAF2, ASF1A, OOEP, HIST1H1D, and ENSG00000112290
Reproduction	Sexual reproduction/reproductive cellular process/gamete generation/oocyte development/fertilization	FIGLA, ZP3, BCL2L10, CCNB1, OOEP, DNMT3A, PTTG1, ZP2, and AMH
Chromatin	Chromosome organization/chromatin assembly or disassembly/chromatin organization	SUV39H2, NCAPH, WHSC1, NCAPG,ASF1A, DNMT3A, PTTG1, HIST1H1D, and DNMT3B
Regulation of cellular process	Positive regulation of macromolecule metabolic process/positive regulation of nitrogen compound metabolic process	BARD1, RAD51, TESC, ASF1A, TTK, and CCNB1
	Regulation of transcription	FUBP1, OTX2, FIGLA, TGS1, MLF1IP, TESC, ASF1A, ZNF77, SUV39H2, HNRNPD, ELAVL2, DNMT3A, and MCM3
	Regulation of apoptosis or cell death	BARD1, TUBB2C, and BCL2L10
DNA	DNA metabolic process	RMI2, BARD1, RAD51, GINS2, ASF1A, DNMT3A, MCM3, and PTTG1
	DNA repair/response to DNA damage stimulus	BARD1, RAD51, ASF1A, and PTTG1
RNA	RNA splicing/mRNA processing/mRNA metabolic process	SRSF2, TGS1, HNRNPD, HNRNPA1L2, and ENSG00000135486
Methylation	Biopolymer methylation/methylation	SUV39H2, TGS1, DNMT3A, and DNMT3B
KEGG_PATHWAY	Cell cycle	BUB1, TTK, CCNB1, MCM3, PTTG1, and CCNB2
	Oocyte meiosis	BUB1, CCNB1, PTTG1, CCNB2, and AURKA
	Progesterone-mediated oocyte maturation	BUB1, CCNB1, and CCNB2
	Spliceosome	SRSF2, HNRNPA1L2, and ENSG00000135486

Functional categories of genes were assembled from annotation and PubMed.