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Down regulation of cell cycle resulted in low proliferation and development in old and old exposure to SHS rats. Quantitative analysis of enzyme-linked immunosorbent assay of cyclin A, B, D, E, p21 and p53. Results are the mean ± SEM (N=6). *p<0.05, **p<0.01, significant statistic difference compared to young control. #p<0.05, significant statistic difference compared to old control.
