Table 2.
Summary of variable sites in terms of amino acids in glycoprotein E2 and NS5B between consensus (of 57 sequences), HCLV India (Reference strain) and different genotypes
| Subgroups | N-terminal of E2 | C-terminal of E2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Antigenic unit B/C | Overlapping | Unit A/D | |||||||||||||
| 705 | 706 | 729 | 736 | 757 | 779 | 780 | 860 | 867 | 868 | 885 | 939 | 960 | 972 | 1034 | |
| Consensus | N | E | N | I | S | V | T | T | F | H | I | T | R | V | L |
| HCLV India | D | E | N | I | S | S | T | T | F | Y | T | A | R | V | L |
| 1.1 | N/D | E | N | I/S | S | S | T | T | F | Y | T | A/T | R | V | L |
| 1.2 | N | E/K | D | I | S | L | T | T | F | Y | M/T | T | R | V | L |
| 1.3 | N | E | D | I | S | S | T | T | F | Y | A | T | R | V | L |
| 2.1 | N | E | D | I | S | A | I | I/M/ | F | Y/H | M/T/K | T | R | V | L |
| Global 2.2 isolates | N/S | E | D | I | S | V | I | M | F | H/Y | M/V/I | T | R | V | L |
| Indian 2.2 isolates | D/N | G/E | N | T/I | S/F | V | T | T/M | Y | H | I | I | K | I/V | M |
| 2.3 | N | E | D | V | S | A | I | I | F | H/Y | K | T | R | V | L |
| Group 3 | N | E | D | I | S | L/S | S/T/I | I/M | F/Y | N/Y/H | T | T | R | I/V | L |
R Arginine, E Glutamate, I Isoleucine, M Methionine, T Threonine, A Alanine, N Asparginine, G Glycine, L Leucine, F Phenylalanine, Y Tyrosine, D Aspartate, H Histidine, K Lysine, S Serine, V Valine