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Compromises in mitochondrial volume and function in parkin Q311X mutants are restored by rapamycin feeding. A, Measurement of mitochondrial volume by EM. **p < 0.01 versus WT. ++p < 0.01 versus Mut. B, Mitochondrial CI activity measured in isolated striatal DAergic synaptosomes as described previously (Chinta et al., 2007). ***p < 0.001 versus WT. ++p < 0.01 versus Mut. Data are from three separate synaptosomal preparations performed in triplicate.
