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Dose-response curve of 7-nitroindazole (7-NI) on extinction of contextual fear conditioning (CFC) in WT mice. 7-NI was administered 30 minutes before the first reexposure to the aversive context. The 15-, 30-, and 60-mg/kg doses facilitate extinction compared with vehicle (n=6–8/group). Results are expressed as means±SEM. S-N-K *P<.05 different from other groups; #P<.05 different from vehicle.
