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. 2015 Mar 6;18(8):pyv010. doi: 10.1093/ijnp/pyv010

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© The Author 2015. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Blockade of brain-derived neurotrophic factor signaling cascade by K252a prevents the antidepressant actions of tetramethylpyrazine (TMP). K252a pretreatment before TMP administration dramatically prevented the TMP-induced decrease in the duration of immobility in the (A) forced swimming test and (B) in the tail suspension test. (C) Chronic social defeat stress (CSDS)-treated mice were co-treated with TMP and K252a for 14 d. CSDS + TMP + K252a mice displayed significantly lower sucrose consumption than CSDS + TMP + artificial cerebrospinal fluid-dimethyl sulphoxide (ACSF/DMSO) mice. (D) Co-treatment of TMP with K252a blocked the antidepressant effect of TMP in the social interaction test. CSDS + TMP + K252a mice displayed significantly lower social interaction than CSDS + TMP + ACSF/DMSO mice. Results are expressed as means ± standard error of the mean (n = 10); * p < 0.01; n.s., no significance. Comparison was made by one-way analysis of variance followed by a post hoc LSD test.