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. 2015 Sep 16;5:14110. doi: 10.1038/srep14110

Figure 6. M1R deficiency augments Trail-R2 expression in HSC and promotes HSC apoptosis.

Figure 6

(A) Compared to WT mice, livers from AOM-treated M1R-deficient mice had 32-fold increased Trail-R2 expression. In PBS-treated mice, M1R deficiency reduced Trail expression. After AOM treatment, Trail expression in WT and M1R-deficient mice was similar, although AOM exposure decreased Trail expression only in WT mice. (B) Representative photomicrographs of liver sections stained for both TUNEL and α-SMA at 200x magnification with 400x insert. Arrows indicate TUNEL (+) activated HSC. (C) After AOM exposure, the proportion of TUNEL-positive HSC was significantly increased in livers from M1R-deficient mice compared to those from WT mice. *p < 0.05, ***p < 0.001 within genotype, and †p < 0.05, †††p < 0.001 within treatment group.