Table 3.
Cox's proportional hazards regression analysis of variables associated with overall survival in the propensity matched cohort
| Variable | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Age at diagnosis | 1.03 (1.02–1.04) | <0.001 | 1.03 (1.02–1.04) | <0.001 |
| Gender | ||||
| Male | Ref | 0.941 | ||
| Female | 1.01 (0.78–1.31) | |||
| Ethnicity | ||||
| White | Ref | – | Ref | – |
| Black | 0.98 (0.70–1.36) | 0.895 | 1.13 (0.80–1.59) | 0.478 |
| Other | 0.55 (0.38–0.78) | <0.001 | 0.53 (0.37–0.76) | 0.001 |
| Alpha-fetoprotein level | ||||
| Normal | Ref | – | Ref | – |
| Elevated | 0.97 (0.65–1.44) | 0.884 | 1.08 (0.73–1.61) | 0.695 |
| Unknown | 0.97 (0.68–1.38) | 0.855 | 0.87 (0.60–1.26) | 0.469 |
| Charlson Comorbidity Score | ||||
| 0 | Ref | – | Ref | – |
| 1 | 1.09 (0.80–1.47) | 0.580 | 1.04 (0.76–1.42) | 0.796 |
| ≥2 | 1.04 (0.72–1.49) | 0.838 | 0.94 (0.64–1.37) | 0.740 |
| Unknown | 0.98 (0.64–1.50) | 0.919 | 1.30 (0.82–2.03) | 0.256 |
| Cirrhosis | ||||
| No | Ref | – | Ref | – |
| Yes | 1.94 (1.03–3.68) | 0.041 | 1.95 (1.01–3.74) | 0.046 |
| Unknown | 1.39 (0.86–2.25) | 0.177 | 1.51 (0.92–2.50) | 0.103 |
| Treatment | ||||
| Ablation | Ref | – | Ref | – |
| Resection | 0.61 (0.47–0.79) | <0.001 | 0.62 (0.48–0.81) | <0.001 |
HR, hazards ratio.