Table 3.
Cox's proportional hazards regression analysis – all patients (n = 235)
| Variable | Univariable | Multivariable | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Age (ref: < 65 years) | 0.89 | 0.63–1.26 | 0.51 | |||
| Male Gender (ref: female) | 1.36 | 0.96–1.92 | 0.08 | 1.13 | 0.78–1.62 | 0.52 |
| CCI >5 (ref: < 5) | 1.86 | 1.19–2.91 | 0.006 | 1.30 | 0.79–2.13 | 0.29 |
| CA19-9 category | ||||||
| Normal: ≤35 | ref | ref | ref | ref | ref | ref |
| Low: 36–200 | 0.90 | 0.56–1.45 | 0.66 | 0.86 | 0.51–1.44 | 0.57 |
| Moderate: 201–1000 | 1.33 | 0.83–2.14 | 0.24 | 0.89 | 0.49–1.60 | 0.71 |
| High: >1000 | 1.76 | 0.98–3.16 | 0.06 | 1.18 | 0.58–2.36 | 0.64 |
| Elevated Preop CA19-9 > 35 (ref: < 35) | 1.98 | 1.38–2.86 | <0.001 | 1.48 | 0.93–2.36 | 0.10 |
| Borderline Resectable (ref: resectable) | 1.89 | 1.31–2.72 | 0.001 | 1.31 | 0.83–2.06 | 0.23 |
| Completed Neoadjuvant Tx and Surgery (ref: no) | 0.15 | 0.10–0.22 | <0.001 | 0.20 | 0.12–0.29 | <0.001 |
| Rec'd Adjuvant therapy (ref: no) | 0.42 | 0.28–0.64 | <0.001 | 0.90 | 0.52–1.53 | 0.69 |
HR, hazard ratio; CI, confidence interval; CCI, Charlson's comorbidity index; CA, carbohydrate antigen.