Figure 1.

Tumor angiogenesis mechanisms. Soluble angiogenic factors (e.g., VEGF, PDGF, FGF) are secreted from the tumor and surrounding cells to induce and regulate key steps in angiogenesis. Reproduced with permission from [1].

Abbreviations: bFGF, basic fibroblast growth factor; bFGFR, basic fibroblast growth factor receptor; MMP, matrix metalloproteinase; PDGF, platelet-derived growth factor; PDGFR, platelet-derived growth factor receptor; VEGF, vascular endothelial growth factor; VEGFR, vascular endothelial growth factor receptor.