Figure 5.
Progress of experimental genetics efforts in rodent malaria parasites. Data have been extracted from the Rodent Malaria genetically modified Parasites database, RMgmDB, as on 28 November 2014 (A. van Wigcheren & C.J. Janse, personal communications).38 Note that the date indicated for each entry is the date when the entry was last modified in the database. Therefore, no entries precede the year 2009 in which the database was initiated. (A) Total number of successfully generated mutants (dashed line) including loss-of-function (black) and endogenously tagged (grey) parasite lines. (B) Number of targetted unique genes. Indicated are successful (solid) and unsuccessful (dotted) attempts to delete (black) or endogenously tag (grey) the genes of interest.