Fig. 3.

(A–F) Assessment of the behavioral changes in the open field test of adult rats following MD lesion at postnatal day 4 (P4). (A) Mean (±SD) locomotor activity; (B) locomotor activity profile over 10  min; (C) animal’s velocity; (D) assessment of the thigmotaxis patterns during 10–min in the open-field; and (E) thigmotaxis time. The index of thigmotaxis and thigmotaxis time were measured during 5 consecutive periods of 2 min. Mean (±SD). * and #: p < 0.05; ** and ##: p  < 0.01, *** and ###: p < 0.001. The “*” refers to the control vs MD lesion group comparison and the “#” refers to the MD sham vs MD lesion group comparison.