Skip to main content
. 2015 Jul 15;290(35):21443–21459. doi: 10.1074/jbc.M115.640425

FIGURE 11.

FIGURE 11.

Large vessels, hearts, and lungs of the Fbln4+/+, Fbln4+/E57K, and Fbln4E57K/E57K mice. A, ascending aortae. Note the two different types of dilations in the Fbln4E57K/E57K ascending aortae. B, left common carotid arteries. The Fbln4E57K/E57K artery is tortuous. C, hearts from Fbln4+/+, Fbln4+/E57K, and Fbln4E57K/E57K mice at age 12 months. The Fbln4E57K/E57K hearts are enlarged. D, histology of large vessels and lungs. Paraffin-embedded sections of ascending aortae (panels a–f), descending thoracic aortae (panels g–l), and lungs (panels m–o) stained with hematoxylin-eosin (HE; panels a–c, g–i, and m–o) and pentachrome reagents (PC; panels d–f and j–l). White arrows indicate discontinuities in elastic laminae of large vessels.