FIGURE 1.

Herpes simplex virus glycoprotein gC and the GAG interaction platform. a, schematic structure of gC. The mucin-like region found in the N-terminal region contains multiple sites for O-linked (green) and N-linked (red) glycosylation and lies close to the positively changed GAG-binding region. The mucin-like region is present in native gC but deleted in gCΔmuc. TMR, transmembrane region. b, electrophoretic profiles of native gC and gCΔmuc. c, schematic image representing the GAG immobilization strategy. d, streptavidin (SA) and GAG mass deposited on the sensor surface measured by SPR, the calculated chain density, and chain-to-chain distance. SAM, self-assembled monolayer.